Fundamental Bases and Cellular Mechanisms of Cancer

Résumé

This book provides a comprehensive exploration of the molecular and cellular mechanisms underlying cancer development and progression. It examines the regulation of the cell cycle, the role of cyclin-dependent kinases, checkpoint pathways, and the molecular alterations leading to uncontrolled cellular proliferation. The book also discusses diverse cell death pathways, including apoptosis, necroptosis, autophagy, ferroptosis, and pyroptosis, highlighting their implications in tumor biology and therapy. In addition, it explores telomere maintenance, cellular immortalization, tumor progression, metastasis, and the genetic and epigenetic alterations associated with carcinogenesis. Emphasizing recent advances in molecular oncology, the work presents current therapeutic strategies targeting cancer-related pathways. Designed for students, researchers, and healthcare professionals, this book bridges fundamental cancer biology with clinical applications, contributing to a deeper understanding of cancer pathogenesis and modern anti-cancer approaches.